[Effectiveness of various schedules of drug therapy of patients with sarcoidosis of the respiratory organs].
Identifieur interne : 003101 ( Main/Exploration ); précédent : 003100; suivant : 003102[Effectiveness of various schedules of drug therapy of patients with sarcoidosis of the respiratory organs].
Auteurs : L V Ozerova ; I E Stepanian ; V V Romanov ; T A KireevaSource :
- Problemy tuberkuleza [ 0032-9533 ] ; 1989.
Descripteurs français
- KwdFr :
- Acide acétylsalicylique (usage thérapeutique), Adulte, Adulte d'âge moyen, Association de médicaments, Association médicamenteuse (usage thérapeutique), Azathioprine (administration et posologie), Azathioprine (usage thérapeutique), Calendrier d'administration des médicaments, Chloroquine (usage thérapeutique), Femelle, Hormones corticosurrénaliennes (administration et posologie), Hormones corticosurrénaliennes (usage thérapeutique), Humains, Maladies lymphatiques (traitement médicamenteux), Maladies pulmonaires (traitement médicamenteux), Mâle, Prednisolone (usage thérapeutique), Sarcoïdose (traitement médicamenteux), Triamcinolone acétonide (usage thérapeutique), Évaluation de médicament.
- MESH :
- administration et posologie : Azathioprine, Hormones corticosurrénaliennes.
- traitement médicamenteux : Maladies lymphatiques, Maladies pulmonaires, Sarcoïdose.
- usage thérapeutique : Acide acétylsalicylique, Association médicamenteuse, Azathioprine, Chloroquine, Hormones corticosurrénaliennes, Prednisolone, Triamcinolone acétonide.
- Adulte, Adulte d'âge moyen, Association de médicaments, Calendrier d'administration des médicaments, Femelle, Humains, Mâle, Évaluation de médicament.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (administration & dosage), Adrenal Cortex Hormones (therapeutic use), Adult, Aspirin (therapeutic use), Azathioprine (administration & dosage), Azathioprine (therapeutic use), Chloroquine (therapeutic use), Drug Administration Schedule, Drug Combinations (therapeutic use), Drug Evaluation, Drug Therapy, Combination, Female, Humans, Lung Diseases (drug therapy), Lymphatic Diseases (drug therapy), Male, Middle Aged, Prednisolone (therapeutic use), Sarcoidosis (drug therapy), Triamcinolone Acetonide (therapeutic use).
- MESH :
- chemical , administration & dosage : Adrenal Cortex Hormones, Azathioprine.
- chemical , therapeutic use : Adrenal Cortex Hormones, Aspirin, Azathioprine, Chloroquine, Drug Combinations, Prednisolone, Triamcinolone Acetonide.
- drug therapy : Lung Diseases, Lymphatic Diseases, Sarcoidosis.
- Adult, Drug Administration Schedule, Drug Evaluation, Drug Therapy, Combination, Female, Humans, Male, Middle Aged.
Abstract
One hundred and seventeen patients with active sarcoidosis of the respiratory organs were treated according to 4 therapy regimens based on the use of corticosteroid drugs. Intermittent use of the corticosteroids was shown to be the most efficient (in 98.5 per cent). It allowed to lower the course dose by 25-30 per cent and to reduce the frequency of complications to 1.5 per cent. Inspite of high efficacy of kenalog 40, its use was limited because of adverse reactions in 19.2 per cent of the patients. It was difficult to eliminate the adverse reactions because of the drug prolonged action. The use of presocyl provided improvement in 62 per cent of the patients having contraindications for corticosteroid therapy. Patients with marked pneumosclerotic lesions should be treated with simultaneous use of corticosteroids and azathioprine.
PubMed: 2726708
Affiliations:
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Le document en format XML
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first="L V" last="Ozerova">L V Ozerova</name></author><author><name sortKey="Stepanian, I E" sort="Stepanian, I E" uniqKey="Stepanian I" first="I E" last="Stepanian">I E Stepanian</name></author><author><name sortKey="Romanov, V V" sort="Romanov, V V" uniqKey="Romanov V" first="V V" last="Romanov">V V Romanov</name></author><author><name sortKey="Kireeva, T A" sort="Kireeva, T A" uniqKey="Kireeva T" first="T A" last="Kireeva">T A Kireeva</name></author></analytic><series><title level="j">Problemy tuberkuleza</title><idno type="ISSN">0032-9533</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (administration & dosage)</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Adult</term><term>Aspirin (therapeutic use)</term><term>Azathioprine (administration & dosage)</term><term>Azathioprine (therapeutic use)</term><term>Chloroquine (therapeutic use)</term><term>Drug Administration Schedule</term><term>Drug Combinations (therapeutic use)</term><term>Drug Evaluation</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Lung Diseases (drug therapy)</term><term>Lymphatic Diseases (drug therapy)</term><term>Male</term><term>Middle Aged</term><term>Prednisolone (therapeutic use)</term><term>Sarcoidosis (drug therapy)</term><term>Triamcinolone Acetonide (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acide acétylsalicylique (usage thérapeutique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Association médicamenteuse (usage thérapeutique)</term><term>Azathioprine (administration et posologie)</term><term>Azathioprine (usage thérapeutique)</term><term>Calendrier d'administration des médicaments</term><term>Chloroquine (usage thérapeutique)</term><term>Femelle</term><term>Hormones corticosurrénaliennes (administration et posologie)</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Maladies lymphatiques (traitement médicamenteux)</term><term>Maladies pulmonaires (traitement médicamenteux)</term><term>Mâle</term><term>Prednisolone (usage thérapeutique)</term><term>Sarcoïdose (traitement médicamenteux)</term><term>Triamcinolone acétonide (usage thérapeutique)</term><term>Évaluation de médicament</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Azathioprine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Aspirin</term><term>Azathioprine</term><term>Chloroquine</term><term>Drug Combinations</term><term>Prednisolone</term><term>Triamcinolone Acetonide</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Azathioprine</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Diseases</term><term>Lymphatic Diseases</term><term>Sarcoidosis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Maladies lymphatiques</term><term>Maladies pulmonaires</term><term>Sarcoïdose</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Acide acétylsalicylique</term><term>Association médicamenteuse</term><term>Azathioprine</term><term>Chloroquine</term><term>Hormones corticosurrénaliennes</term><term>Prednisolone</term><term>Triamcinolone acétonide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Drug Administration Schedule</term><term>Drug Evaluation</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Calendrier d'administration des médicaments</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Évaluation de médicament</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">One hundred and seventeen patients with active sarcoidosis of the respiratory organs were treated according to 4 therapy regimens based on the use of corticosteroid drugs. Intermittent use of the corticosteroids was shown to be the most efficient (in 98.5 per cent). It allowed to lower the course dose by 25-30 per cent and to reduce the frequency of complications to 1.5 per cent. Inspite of high efficacy of kenalog 40, its use was limited because of adverse reactions in 19.2 per cent of the patients. It was difficult to eliminate the adverse reactions because of the drug prolonged action. The use of presocyl provided improvement in 62 per cent of the patients having contraindications for corticosteroid therapy. Patients with marked pneumosclerotic lesions should be treated with simultaneous use of corticosteroids and azathioprine.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kireeva, T A" sort="Kireeva, T A" uniqKey="Kireeva T" first="T A" last="Kireeva">T A Kireeva</name><name sortKey="Ozerova, L V" sort="Ozerova, L V" uniqKey="Ozerova L" first="L V" last="Ozerova">L V Ozerova</name><name sortKey="Romanov, V V" sort="Romanov, V V" uniqKey="Romanov V" first="V V" last="Romanov">V V Romanov</name><name sortKey="Stepanian, I E" sort="Stepanian, I E" uniqKey="Stepanian I" first="I E" last="Stepanian">I E Stepanian</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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